Carvedilol - more than --blocker--blocker, is a nonselective antagonist of --adrenoceptors and -_{1--arrestin-mediated signaling pathway, generate nitric oxide (NO), block -3-adrenoceptors and change flow of ions. Moreover, both carvedilol and several of its metabolites act as potent antioxidants. The drug presents also anti-inflammatory, anticoagulation and antiproliferation properties. Carvedilol leads to plaque stabilization, inhibits cardiac remodeling and apoptosis as well as produces cardioprotective, neuroprotective and antiarrhythmic effects. Pleiotropic action of carvedilol leads to its exceptional effectiveness in the therapy of circulatory system.}-adrenoreceptor. Accumulated experimental data indicate its pleiotropic actions. The drug is able to stimulate . Carvedilol, the third generation of

Keywords: carvedilol, mechanism of action.