Ewa Zawadzka
Formulacja przeciwzapalnych i nawilżających kropli do oczu z zastosowaniem polimeru bioadhezyjnego (metylocelulozy)
2009-11-04
Formulation of anti-inflammatory and moisturizing eye drops with application of bioadhesive polymer (methylcellulose). The preparation of vehicles for eye drops and their application forms containing diclofenac sodium (DNa) and bioadhesive polymer methylcellulose (MH Tylose 300 and Methocel MC 400), and dexpanthenol. The pH, osmolarity (), viscosity () and surface tension () for all investigated compositions of vehicles for eye drops and their application forms with DNa and dexpanthenol were determined. The critical micellar concentration (cmc) for adducts forming from the formulation components of the vehicle for eye drops was determined. Calculation of cmc has enabled for the calculation of micellar hydrophilic lipophilic balance (HLBcmc) acc. to the method by Lin, Davies and Griffin, and of the thermodynamic potential of micelle formation (Gm0). The diffusion rate of ionic stream from eye drops with DNa through the dialyser to the external compartment (water) was measured. The measurements were done by conductometric method.Keywords: diclofenac sodium, methylcellulose, eye drops, dexpanthenol.
Formulacja przeciwzapalnych i nawilżających kropli do oczu z zastosowaniem polimeru bioadhezyjnego (metylocelulozy)
159.25 kB |
21 grudnia 2017