Anna Banyś, Lucyna Bułaś, Ewa Długosz, Beata Szulc-Musiał, Andrzej Jankowski
Angiogeneza w chorobie nowotworowej
2009-03-25
Angiogenesis is the process of the formation of new blood-vessels which appears conditioned physiological, but also in the pathogenesis of many diseases. Most sizable from them is cancer. New vessels provide the neoplastic tissue into oxygen, healthful components and make possible the exchange of metabolites. The besides suitable blood supply of the tumour favours to getting itself oncocytes to bloodstream and, consequently, to initiating of the process of the formation of metastasises. Angiogenesis indicator is the density of vessels MVD. On the ground research of the computer scanning and the magnetic resonance one ascertained that enlarged number of vessels in the tumour was connected with the quicker progression of the disease and a worse prognosis. Prognosing of the course of the neoplastic disease one can lean also on the ground marks of the expression of genes coding angiogenesis factors. The meaning of these research has a clinical reason and permits to find useful prognostic factors, diagnostic markers and to trace new therapeutic targets across the introduction of medicines of the new generation.Keywords: angiogenesis, cancer.