Katarzyna Sosnowska, Katarzyna Winnicka, Anna Czajkowska-Kośnik
Porównanie stabilności pediatrycznych zawiesin z maleinianem enalaprilu wykonanych z tabletek różnych producentów
2009-03-25
In this paper, the stability of enalapril maleate in oral formulations prepared from commercially available tablets was examined. Extemporaneously compounded, 0.1 mg/mL and 1.0 mg/mL, oral suspensions of enalapril maleate in sugar-containing and sugar-free vehicles were stored in the absence of light at 4° and 25°C for 30 days. Viscosities and pH of all tested formulations did not significantly change over 30 days both at 25° and 4° C. All the formulations retain minimum 98% of the initial enalapril maleate concentration after 30 days of storage and they may provide an option in situations when the marketed suspension is unavailable.Keywords: stability, enalapril maleate, oral suspension, pediatric dosage form, high-performance liquid chromatography.
Porównanie stabilności pediatrycznych zawiesin z maleinianem enalaprilu wykonanych z tabletek różnych producentów
160.07 kB |
21 grudnia 2017