Katarzyna Małolepsza-Jarmołowska

Wpływ glikolu propylenowego-1,2 na uwalnianie metronidazolu z żeli zawierających kompleks kwasu mlekowego z Eudragitem E-100
2006-05-01

Influence of polypropylene glycol 1,2 on metronidazole release from gels containing lactic acid complexed with Eudragit E-100. Metronidazole release form methylcellulose gels containing lactic acid complexed with Eudragit E-100 in 1:1, 2:1, 3:1 and 4:1 molar ratio was shown to be differentiated. Half-release time is from 33 to 77 hours. This will enable selection of a preparation with optimum metronidazole release rate providing its antibacterial level at the site of application.