Arkadiusz Kazula, Ewa Kazula
Proteasomy a nowe kierunki terapii
2009-09-15
Proteasome a new trend in therapy. The 26S proteasome is a large intracellular protease that identifies and degrades proteins. The orderly degradation of cellular proteins is critical for normal cell cycling and function, and inhibition of the proteasome pathway results in cell-cycle arrest and apoptosis. Dysregulation of this enzymatic system may also play a role in tumor progression, drug resistance, and altered immune surveillance, making the proteasome an appropriate and novel therapeutic target in cancer. The ubiquitin-proteasome pathway is just beginning to be exploited as a target for cancer therapy. Nonetheless, given the available molecular biological, preclinical, and clinical data, there is very good reason to be optimistic that current drugs and future candidates will contribute significantly to the care of patients with cancer. This article discusses proteasome inhibition as a novel therapeutic target in cancer and focuses on the development, mechanism of action.Keywords: Proteasome, ubiquitin-proteasome pathway, novel therapeutic target.