The peculiar relationship between pharmacist and hypertensive patient ń new perspectives and possibilities. Epidemiological studies have shown that about 30% Polish adults suffer from essential hypertension. Hypertension is the main risk factor for coronary heart disease, heart failure, renal failure and cause of death. Therefore, the evaluation of mechanisms responsible for saltwater regulation to improve hypertension treatment became one of the main topics of Sixth Frame Work Programme supported by UE. The aging of European population will increase the number of people with hypertension. All of these persons will have contact with pharmacists quite often. Thus, the role of pharmacist in the prevention and treatment of hypertension should not be omitted. Pharmacists shall help not only by selling antihypertensive drugs, but also by active participation in patientsi education and non pharmacological therapies. Professional information about causes, risk factors and threatening complications of hypertension may be also helpful. Pharmacist may convince patients to take drugs regularly, encourage them to change the life style and participate in hypertension monitoring by regular blood pressure measurements in pharmacies. Pharmacist has to give and collect all information associated with sold drugs. In recent years many new drugs have been registered. An appropriate selection of antihypertensive, first choice drugs should rely primarily on individual characteristics of patient and other disorders accompanying hypertension. Pharmacist supports doctor in choosing the proper drug by taking under consideration many factors, such us good efficacy and tolerance of the drug, the best form of the drug, availability, price and patients economic situation. The advantages of new forms of tablets (e.g. slow or modified release tablets) shall also be significant. One of the most important tasks of pharmacist, especially in countries where the economic situation of society is below average, is choosing between original or generic drugs. Pharmacoeconomic analysis may often help to make a proper decision. Finally pharmacist has to inform patients about specific adverse reactions of drugs, collect signs from patients about adverse reaction and inform appropriate health departments. If more than one drug is used to control the blood pressure or patient is taking other drugs, pharmacist has to choose drugs carefully to avoid clinically important interactions. The relationship between pharmacist and patient in the hypertension preventing-treating process is very important. It must rely on reliable knowledge, evidence based medicine and pharmacoeconomic analysis.