Dorota Marszałek, Anna Goldnik, Aleksander P. Mazurek, Małgorzata Balicka, Agnieszka Koziorowska, Agnieszka Hermanowicz, Monika Łuka, Milena Piątkowska, Sylwia Grodzka, Sylwia Kumorowska

Stability of new anticonvulsant derivatives of picolinic, icotinic, cyclocarboxylic acids in body fluids and tis-sues.
2014-03-27

The stability of new compounds with established anticonvulsant activity: picolinic acid 4-pyridylmethylamide (Pic-4-PMA), cyclopentanecarboxylic acid benzylamide (Cpc-BZA), cycloheptanecarboxylic acid benzylamide (Chc-BZA), picolinic acid 2-fluoro-3-trifluoromethylbenzylamide (Pic-2F-3TFM-BZA), 2-chloronicotinic acid benzylamide (2-Cl-Na-BZA), 6-chloronicotinic acid benzylamide (6-Cl-Na-BZA) and 6-trifluoromethylnicotinic acid benzylamide (6-TFM-Na-BZA) in homogenates of body organs and in body fluids was determined after incubation. It was found that three compounds were stable against enzymes present in body fluids and organs and two were found to decompose in liver and kidney homogenates and two decomposed only in liver homogenate.
Keywords: picolinic, nicotinic and cyclocarboxylic acid derivatives, anticonvulsant activity